反应详情

A mixture of 6.5 g (0.04 mole) of 1-phenylpiperazine, 8.4 g (0.042 mole) of 4-chloro-1-phenoxy-2-butanol and 15.9 g (0.15 mole) of anhydrous sodium carbonate in 200 ml of 1-butanol was heated at reflux 20 hr. The mixture was concentrated under reduced pressure and the residue was partitioned between water and benzene. The benzene layer was washed with water and aqueous saturated sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure to give the title product in the residue which was recrystallized from isopropyl alcohol to give 8.9 g (68%) of white powder, m.p. 93°-94° C.

1. temperaturewas heated
2. temperatureat reflux 20 hr
3. concentrationThe mixture was concentrated under reduced pressure
4. customthe residue was partitioned between water and benzene
5. washThe benzene layer was washed with water and aqueous saturated sodium chloride solution
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated under reduced pressure