Potassium Iodide → Hydrochloric Acid

Participants

Reaction Steps

This compound was prepared according to the procedure of Example 97. A mixture of 5.0 g (0.03 mole) of 1-(2-pyridyl)piperazine, 7.0 g (0.03 mole) of 4-chloro-1-(4-chlorophenoxy)-2-butanol, 16.0 g (0.15 mole) of anhydrous sodium carbonate and 0.3 g (0.002 mole) of potassium iodide in a total volume of 200 ml of 1-butanol gave a golden oil as residue. The hydrochloride was formed in 2-propanol saturated with hydrogen chloride and the collected solid was recrystallized from aqueous 2-propanol to give 8.1 g (62%) of white solid, m.p. >245° C.

Provenance & Evidence