Potassium Iodide → Hydrochloric Acid

Participants

Reaction Steps

This compound was prepared according to the procedure of Example 97. A mixture of 6.5 g (0.03 mole) of 4-chloro-1-(4-fluorophenoxy)-2-butanol, 5.4 g (0.03 mole) of 1-(4-fluorophenyl)piperazine, 16.0 g (0.15 mole) of anhydrous sodium carbonate and 0.3 g (0.002 mole) of potassium iodide in a total volume of 200 ml of 1-butanol gave a golden oil as residue. The hydrochloric acid salt was formed in 2-propanol saturated with hydrogen chloride, and the collected solid was recrystallized from methanol-water-ethyl ether to give 6.7 g (56%) of white solid, m.p. 161°-165° C.

Provenance & Evidence