Acetic Anhydride → HCID 54504884, compound

HRID 1382477Notes

Reaction equation

HRID 1382477 reaction equation
C([C:3]1[CH:4]=[C:5]([C:9]2[C:10]([NH:12][C:13](=[O:15])[CH:14]=2)=[O:11])[CH:6]=[CH:7][CH:8]=1)#C.[CH:16]([O:20]C1C=CC(N)=CC=1)=[CH:17][CH2:18][CH3:19].C1(=O)OC(=O)C=C1.C(OC(=O)C)(=O)C>C([O-])(=O)C.[Ni+2].C([O-])(=O)C.CC(C)=O>[CH:16]([O:20][C:8]1[CH:3]=[CH:4][C:5]([C:9]2[C:10]([NH:12][C:13](=[O:15])[CH:14]=2)=[O:11])=[CH:6][CH:7]=1)=[CH:17][CH2:18][CH3:19]

Participants

7

Reactant 4

HCID 7918Acetic AnhydrideHCID 7923Maleic AnhydrideHCID 19853728HCID 19853728, compoundHCID 54096058HCID 54096058, compound

Product 1

HCID 54504884HCID 54504884, compound

Reagents, catalysts & solvents 2

HCID 9756Nickel AcetateCatalystHCID 180AcetoneSolvent

Procedure

The procedure is the same for 3-ethynylphenyl maleimide. The following amounts of staring materials were used: 4-butenyloxyaniline (4.0 g, 24.5 mmol), maleic anhydride (2.4 g, 24.5 mmol), acetone (100 ml) triethylamine (5 ml), nickel (II) acetate (0.25 g, 3.5 mmol), and acetic anhydride (2.75 g, 27 mmol). Yield=5.0 g, (84%).

Sources & evidence

ORD record
ord-e659dd84eb1e4d769ecb2b614e3dc117
Source dataset
uspto-grants-1989_02
Patent number
US04806608

Reaction notes

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