Hydrazine hydrate (1:1) → 5-fluoro-3-(1-methyl-4-piperidinyl)-1H-indazole

HRID 1382616Notes

Reaction equation

HRID 1382616 reaction equation
F[C:2]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=O.O.[NH2:19][NH2:20]>O>[F:17][C:14]1[CH:13]=[C:3]2[C:2](=[CH:16][CH:15]=1)[NH:20][N:19]=[C:4]2[CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 140324954-(2,5-Difluorobenzoyl)-1-methylpiperidine

Product 1

HCID 1784802385-fluoro-3-(1-methyl-4-piperidinyl)-1H-indazoleYield 22%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4-(2,5-difluorobenzoyl)-1-methylpiperidine of Example 111 (38.5 g, 0.16 moles) and hydrazine monohydrate (79.5 g, 1.59 moles) was heated in an autoclave at 150° for 22 hours. The autoclave was cooled in an ice bath and then opened. The reaction mixture was poured into H2O, causing the product to crystallize. The product was collected and then recrystallized twice from toluene to yield 8.2 g (22%) of 5-fluoro-3-(1-methyl-4-piperidinyl)-1H-indazole, m.p. 202°-204°.

Workup

  1. temperaturewas heated in an autoclave at 150° for 22 hours
  2. temperatureThe autoclave was cooled in an ice bath
  3. customto crystallize
  4. customThe product was collected
  5. customrecrystallized twice from toluene

Sources & evidence

ORD record
ord-e82359de00e34f5b8a513021fdc83aa7
Source dataset
uspto-grants-1989_02
Patent number
US04806649

Reaction notes

Loading…