Morpholine → HCID 13292773, compound

HRID 1382628Notes

Reaction equation

HRID 1382628 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8](/[C:11](/[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:12](\[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)/[C:13]([F:16])([F:15])[F:14])=[CH:7][CH:6]=1.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[C:23]1(/[C:11](/[C:8]2[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[CH:6][CH:7]=2)=[C:12](/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)\[C:13]([F:16])([F:15])[F:14])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 13292770HCID 13292770, compound

Product 1

HCID 13292773HCID 13292773, compoundYield 82.4%

Procedure

A mixture of 3.34 g (7.5 mmoles) of (E)-1-[4-(2-bromoethoxy)-phenyl]-1,2-diphenyl-3,3,3-trifluoro-propene, prepared as described in Example 7, and 13 g of morpholine is boiled for one hour. The reaction mixture is processed as described in Example 1, and the crude product is crystallized from hexane. 2.80 g (82.4%) of the aimed compound are obtained; m.p.: 84°-89° C.

Workup

  1. customprepared
  2. customthe crude product is crystallized from hexane

Sources & evidence

ORD record
ord-179309e8afc44b1093e21edddd2b1c6f
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

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