Hydrochloric Acid → HCID 70377428, compound

HRID 1382646Notes

Reaction equation

HRID 1382646 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:39])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([C:29]2[CH:34]=[CH:33][C:32]([O:35]COC)=[CH:31][CH:30]=2)=[C:14]([C:19]2[CH:24]=[CH:23][C:22]([O:25]COC)=[CH:21][CH:20]=2)[C:15]([F:18])([F:17])[F:16])=[CH:9][CH:8]=1>CO>[ClH:1].[CH3:39][N:3]([CH3:2])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([C:29]2[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=2)=[C:14]([C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)[C:15]([F:16])([F:17])[F:18])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54557953HCID 54557953, compound

Product 1

HCID 70377428HCID 70377428, compoundYield 74.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 ml of a 9% methanolic hydrochloric acid are added to a solution of 4.0 g (7.47 mmoles) of 1-[4-(2-dimethylaminoethoxy)-phenyl]-3,3,3-trifluoro-1,2-bis-(4-methoxymethoxyphenyl)-propene in 40 ml of methanol, and the mixture is boiled for one hour. The solution is evaporated to dryness, and the residue is crystallized from ethanol. 2.67 g (74.4%) of the desired compound are obtained; m.p.: 256°-262° C.

Workup

  1. customThe solution is evaporated to dryness
  2. customthe residue is crystallized from ethanol

Sources & evidence

ORD record
ord-4e79114f68974e6ab6feaa23efe8506b
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

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