Hydrochloric Acid → HCID 54402105, compound

HRID 1382647Notes

Reaction equation

HRID 1382647 reaction equation
Cl.[C:2]1([C:8]([C:35]([F:38])([F:37])[F:36])=[C:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[CH:22][CH:21]=2)[C:10]2[CH:15]=[CH:14][C:13]([O:16]COC)=[CH:12][CH:11]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[C:2]1([C:8]([C:35]([F:38])([F:37])[F:36])=[C:9]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[CH:22][CH:21]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53663431HCID 53663431, compound

Product 1

HCID 54402105HCID 54402105, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 ml of a 9% methanolic hydrochloric acid are added to a solution of 3.08 g (6 mmoles) of 2-phenyl-3,3,3-trifluoro-1-[4-(2-morpholinoethoxy)-phenyl]-1-(4-methoxymethoxy-phenyl)-propene in 40 ml of methanol, and the mixture is boiled for one hour. The solution is rendered alkaline with 1.5 ml of a 10 n sodium hydroxide solution and then evaporated. The residue is dissolved in 400 ml of ether, the solution is washed with water until neutral, dried and evaporated. The residue is crystallized from acetone. 2.23 g (73.6%) of the aimed compound are obtained; m.p.: 154°-157° C.

Workup

  1. customevaporated
  2. dissolutionThe residue is dissolved in 400 ml of ether
  3. washthe solution is washed with water until neutral,
  4. customdried
  5. customevaporated
  6. customThe residue is crystallized from acetone

Sources & evidence

ORD record
ord-a5e7acdc5f22447caf1fe9c947de27c7
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

Loading…