Hydrochloric Acid → HCID 70377387, compound

HRID 1382649Notes

Reaction equation

HRID 1382649 reaction equation
[ClH:1].[C:2]1([C:8]([C:31]([F:34])([F:33])[F:32])=[C:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][NH:29][CH3:30])=[CH:22][CH:21]=2)[C:10]2[CH:15]=[CH:14][C:13]([O:16]COC)=[CH:12][CH:11]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[ClH:1].[C:2]1([C:8]([C:31]([F:32])([F:33])[F:34])=[C:9]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][NH:29][CH3:30])=[CH:22][CH:21]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53912477HCID 53912477, compound

Product 1

HCID 70377387HCID 70377387, compoundYield 71.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.5 ml of a 9% methanolic hydrochloric acid are added to a solution of 1.50 g (3.28 mmoles) of 2-phenyl-3,3,3-trifluoro-1-[4-(2-methylaminoethoxy)-phenyl]-1-(4-methoxymethoxy-phenyl)-propene in 15 ml of methanol, and the mixture is boiled for one hour. The solution is evaporated to dryness, and the residue is crystallized from isopropanol. 1.06 g (71.6%) of the aimed compound are obtained; m.p.: 213°-218° C.

Workup

  1. customThe solution is evaporated to dryness
  2. customthe residue is crystallized from isopropanol

Sources & evidence

ORD record
ord-071f30d5714a4affa3c31f82b4607700
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

Loading…