反应详情

A mixture of 14.4 g of 1-(2-nonylphenyl)-1-hexanol, 2 g of toluene-4-sulphonic acid monohydrate and 250 ml of toluene is heated under reflux for 3 hours using a water separator. After cooling, the reaction mixture is washed twice with 10% strength (w/v) sodium bicarbonate solution and twice with water. The organic phase is dried over sodium sulphate and concentrated by evaporation in vacuo, and the residue is purified by chromatography on silica gel using hexene as eluant. The desired 1-(2-nonylphenyl)-trans-hexene is obtained in the form of a pale yellow oil.

1. temperatureis heated
2. temperatureunder reflux for 3 hours
3. temperatureAfter cooling
4. washthe reaction mixture is washed twice with 10% strength (w/v) sodium bicarbonate solution and twice with water
5. dry with materialThe organic phase is dried over sodium sulphate
6. concentrationconcentrated by evaporation in vacuo
7. customthe residue is purified by chromatography on silica gel