反应详情

A suspension of 92 g of 1-benzyl 4-trifluoromethylcarbonylamino piperidine (X) and 9 g of wet 10% palladium on charcoal in 1000 ml of methanol is left under agitation for 8 days in a hydrogen atmosphere at room temperature. Then it is filtered, the filtrate is evaporated and the residue chromatographed on a silica column (M.P.L.C.). By eluting with pure methanol, 44 g of the expected product are obtained.

1. filtrationThen it is filtered
2. customthe filtrate is evaporated
3. customthe residue chromatographed on a silica column (M.P.L.C.)
4. washBy eluting with pure methanol, 44 g of the expected product
5. customare obtained