Sodium Sulfate → HCID 14350504, compound

HRID 1382714Notes

Reaction equation

HRID 1382714 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][C:11]3[C:13]([OH:18])=[CH:14][CH:15]=[C:16]([OH:17])[C:10]=3[N:9]=2)=[CH:4][CH:3]=1.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCOCC1.[Ag]=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]3[C:16](=[O:17])[CH:15]=[CH:14][C:13](=[O:18])[C:11]=3[N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 24436Sodium SulfateHCID 14350502HCID 14350502, compound

Product 1

HCID 14350504HCID 14350504, compoundYield 20.2%

Reagents, catalysts & solvents 2

HCID 92152Silver(II) oxideCatalystHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 1.0 g of 2-(4-chlorophenyl)-1H-benzimidazole-4,7-diol, 4 g of sodium sulfate and 1.3 g of silver oxide was stirred in p-dioxane for 12 hours and then filtered. The filtrate was evaporated and the residue crystallized from ethanol, giving 200 mg of the desired product as an orange solid, mp 270°-272° C. (dec.).

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated
  3. customthe residue crystallized from ethanol

Sources & evidence

ORD record
ord-10be02a2734a45ae8b776c4ea3160ce0
Source dataset
uspto-grants-1989_02
Patent number
US04808586

Reaction notes

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