Sodium Azide → HCID 14304685, compound

HRID 1382718Notes

Reaction equation

HRID 1382718 reaction equation
Cl[C:2]1[C:11]2[C:10](=[O:12])[N:9]([CH3:13])[C:8](=[O:14])[N:7]([CH3:15])[C:6]=2[N:5]=[CH:4][CH:3]=1.[N-:16]=[N+:17]=[N-:18].[Na+]>CN(C=O)C>[N:16]([C:2]1[C:11]2[C:10](=[O:12])[N:9]([CH3:13])[C:8](=[O:14])[N:7]([CH3:15])[C:6]=2[N:5]=[CH:4][CH:3]=1)=[N+:17]=[N-:18]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 143046845-Chloro-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Product 1

HCID 14304685HCID 14304685, compoundYield 83.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.35 g of Compound 1 was dissolved in 10 ml of DMF and 0.52 g of 90% sodium azide was added thereto. The solution was stirred for 6 hr at room temperature and the solvent was distilled off under reduced pressure. After adding water, the resulting crystals were separated by filtration to give 1.16 g of 5-azido-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 3)

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionAfter adding water
  3. customthe resulting crystals were separated by filtration

Sources & evidence

ORD record
ord-0fb6b87646764e8f8c9010c834ed242d
Source dataset
uspto-grants-1989_02
Patent number
US04808587

Reaction notes

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