1,1-Dibutoxytrimethylamine → HCID 178481358, compound

HRID 1382721Notes

Reaction equation

HRID 1382721 reaction equation
[C:1]([C:4]1[C:5](=[O:14])[N:6]([CH3:13])[C:7](=[O:12])[N:8]([CH3:11])[C:9]=1[NH2:10])(=[O:3])[CH3:2].[CH2:15](OC(OCCCC)N(C)C)CCC>CN(C=O)C>[OH:3][C:1]1[C:4]2[C:5](=[O:14])[N:6]([CH3:13])[C:7](=[O:12])[N:8]([CH3:11])[C:9]=2[N:10]=[CH:15][CH:2]=1

Participants

4

Reactant 2

HCID 876831,1-DibutoxytrimethylamineHCID 3200235-Acetyl-6-amino-1,3-dimethyluracil

Product 1

HCID 178481358HCID 178481358, compoundYield 70.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

0.8 g of 5-acetyl-6-amino-1,3-dimethyluracil was dissolved in DMF and 4 ml of dimethylformamide dibutylacetal was added thereto. The solution was heated for 8 hr at 80° C. and distilled under reduced pressure. After purification by silica gel column chromatography, the crude product was recrystallized from ethanol to give 0.59 g of 5-hydroxy1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 14).

Workup

  1. distillationdistilled under reduced pressure
  2. customAfter purification by silica gel column chromatography
  3. customthe crude product was recrystallized from ethanol

Sources & evidence

ORD record
ord-303b74edd28c4f0da0843227cddd9aa1
Source dataset
uspto-grants-1989_02
Patent number
US04808587

Reaction notes

Loading…