Methane → 6-Amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

HRID 1382724Notes

Reaction equation

HRID 1382724 reaction equation
[N+:1]([C:4]1[CH:17]=[N:16][C:7]2[N:8]([CH3:15])[C:9](=[O:14])[N:10]([CH3:13])[C:11](=[O:12])[C:6]=2[CH:5]=1)([O-])=O.C>CO.[Pd]>[NH2:1][C:4]1[CH:17]=[N:16][C:7]2[N:8]([CH3:15])[C:9](=[O:14])[N:10]([CH3:13])[C:11](=[O:12])[C:6]=2[CH:5]=1

Participants

5

Reactant 2

HCID 297MethaneHCID 14304691HCID 14304691, compound

Product 1

HCID 89345846-Amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dioneYield 71.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.08 g of Compound 16 was dissolved in methanol and reduced in the presence of 100 mg of Pd-C. Activated charcoal powder was added, and the solution was heated and filtered. The filtrate was distilled under reduced pressure and the residue was recrystallized from methanol to give 0.05 g of 6-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 17).

Workup

  1. temperaturethe solution was heated
  2. filtrationfiltered
  3. distillationThe filtrate was distilled under reduced pressure
  4. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-f5d19da552a44f4fbfaddcc3a5fa7ed7
Source dataset
uspto-grants-1989_02
Patent number
US04808587

Reaction notes

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