Sodium Carbonate → HCID 178481359, compound

HRID 1382725Notes

Reaction equation

HRID 1382725 reaction equation
[NH2:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[C:12](=[O:16])[CH2:13][C:14]#[N:15].C(=O)([O-])[O-].[Na+].[Na+]>O>[NH2:15][C:14]1[CH:13]=[C:12]([OH:16])[C:3]2[C:4](=[O:11])[N:5]([CH3:10])[C:6](=[O:9])[N:7]([CH3:8])[C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 23636893-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-oxopropanenitrile

Product 1

HCID 178481359HCID 178481359, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.21 g of 6-amino-5-(2-cyanoacetyl)-1,3-dimethyluracil and 2.90 g of sodium carbonate were added to 20 ml of water, and the solution was heated under reflux for 1 hr. After cooling, the precipitate was separated from the solution by filtration to give 1.09 g of 7-amino-5-hydroxy-1,3dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 18).

Workup

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 1 hr
  3. temperatureAfter cooling
  4. customthe precipitate was separated from the solution by filtration

Sources & evidence

ORD record
ord-38c1d13621994b26a4e3470289652e16
Source dataset
uspto-grants-1989_02
Patent number
US04808587

Reaction notes

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