反应详情

Ethyl acrylate (326 g) and chloroform (2 l) were added to 1-formylpiperazine (320 g) and the mixture was stirred at room temperature for 3 days. The solvent was distilled off under reduced pressure to give crude 4-ethoxycarbonylethyl-1-formylpiperazine (580 g).

1. distillationThe solvent was distilled off under reduced pressure