Hydrochloric Acid → Piperazin-1-ol dihydrochloride

Participants

Reaction Steps

3N Hydrochloric acid (50 ml) was added to 1-formyl-4-hydroxypiperazine (5.0 g) and the mixture was stirred at 77° to 87° C. for 20 minutes. After stirring, water was distilled off under reduced pressure to a pale yellow residue, which was washed with ethanol and recrystallized from a mixed solvent of water - ethanol to give 1-hydroxypiperazine dihydrochloride (5.0 g) as light brown prisms, m.p. 164°-175° C. (dec.).

Provenance & Evidence