Hydrochloric Acid → Piperazin-1-ol dihydrochloride
Reaction equation
C([N:3]1[CH2:8][CH2:7][N:6]([OH:9])[CH2:5][CH2:4]1)=O.[ClH:10]>>[ClH:10].[ClH:10].[OH:9][N:6]1[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]1Participants
3
Procedure
3N Hydrochloric acid (50 ml) was added to 1-formyl-4-hydroxypiperazine (5.0 g) and the mixture was stirred at 77° to 87° C. for 20 minutes. After stirring, water was distilled off under reduced pressure to a pale yellow residue, which was washed with ethanol and recrystallized from a mixed solvent of water - ethanol to give 1-hydroxypiperazine dihydrochloride (5.0 g) as light brown prisms, m.p. 164°-175° C. (dec.).
Workup
- stirringAfter stirring
- distillationwater was distilled off under reduced pressure to a pale yellow residue, which
- washwas washed with ethanol
- customrecrystallized from a mixed solvent of water - ethanol
Sources & evidence
- ORD record
- ord-8d87dfa7c6f84468b97bb16a35f82b80
- Source dataset
- uspto-grants-1989_02
- Patent number
- US04808584
Reaction notes
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