HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → S-(4-dimethylaminomethyl-2-pyridylmethyl)isothiourea trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 2-Chloromethyl-4-dimethylaminomethylpyridine dihydrochloride | HCID 13292603 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | S-(4-dimethylaminomethyl-2-pyridylmethyl)isothiourea trihydrochloride | HCID 21273288 | 125% |
Reaction Steps
2-Chloromethyl-4-(dimethylaminomethyl)pyridine dihydrochloride (14.67 g) was added to a refluxing solution of thiourea (4.34 g) in ethanol (120 ml) and the solution refluxed for 3 hours, whereupon solid precipitated. After cooling the mixture (ice bath), the solid was filtered and recrystallised from methanolethanol to give S-(4-dimethylaminomethyl-2-pyridylmethyl)isothiourea trihydrochloride (11.88 g), m.p. 175°-9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04808589 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-4bda33e3c7da4ac080b2556f1600d523 |
| Source note | uspto-grants-1989_02 |