Ethyl 2-oxocyclohexylacetate → 9-p-Chlorobenzyl-6,8-dimethyl-1,2,3,4-tetrahydrocarbazol-1-yl-acetic acid

HRID 1382836Notes

Reaction equation

HRID 1382836 reaction equation
[ClH:1].[CH3:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:4]=1[NH:10]N.CC[O:14][C:15]([CH2:17][CH:18]1[C:23](=O)[CH2:22][CH2:21][CH2:20][CH2:19]1)=[O:16]>>[Cl:1][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][N:10]2[C:23]3[CH:18]([CH2:17][C:15]([OH:14])=[O:16])[CH2:19][CH2:20][CH2:21][C:22]=3[C:5]3[C:4]2=[C:3]([CH3:2])[CH:8]=[C:7]([CH3:9])[CH:6]=3)=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 91229Ethyl 2-oxocyclohexylacetateHCID 162130592,4-Dimethylphenylhydrazine hydrochloride

Product 1

HCID 143725069-p-Chlorobenzyl-6,8-dimethyl-1,2,3,4-tetrahydrocarbazol-1-yl-acetic acid

Procedure

Following the procedure of Example 34, but using 1-(2,4-dimethylphenyl)hydrazine hydrochloride and ethyl 2-cyclohexanone acetate in Step I as starting materials, the title compound was prepared. m.p. 187°-188° C.

Sources & evidence

ORD record
ord-ee9faac5eb0d48ab81ae57cfcebc1ed0
Source dataset
uspto-grants-1989_02
Patent number
US04808608

Reaction notes

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