Hydrazine hydrate (1:1) → HCID 178422576, compound

HRID 1382877Notes

Reaction equation

HRID 1382877 reaction equation
Cl[C:2]1[N:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:3]=1[C:4]([C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=1)=O.O.[NH2:27][NH2:28]>N1C=CC=CC=1>[C:12]([C:10]1[CH:11]=[C:6]([C:4]2[C:3]3[C:2](=[N:24][C:23]([CH3:25])=[CH:22][CH:21]=3)[NH:28][N:27]=2)[CH:7]=[C:8]([C:17]([CH3:19])([CH3:18])[CH3:20])[C:9]=1[OH:16])([CH3:15])([CH3:13])[CH3:14]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14368273HCID 14368273, compound

Product 1

HCID 178422576HCID 178422576, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The similar procedures in Example 1 by using 15.5 g of 4-(2-chloro-6-methylnicotinoyl)-2,6-di-tertiary butylphenol, 9.7 g of hydrazine hydrate and 85 ml of pyridine are carried out, and then the obtained crude crystals are recrystallized from ethanol to give 11.8 g of 3-(3,5-di-tertiary butyl-4-hydroxyphenyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine as white crystals, melting at 239°-240° C.

Workup

  1. customthe obtained crude crystals
  2. customare recrystallized from ethanol

Sources & evidence

ORD record
ord-84a738affc7d420a9e01276a10189b69
Source dataset
uspto-grants-1989_02
Patent number
US04808620

Reaction notes

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