Hydrazine hydrate (1:1) → HCID 178423642, compound

HRID 1382878Notes

Reaction equation

HRID 1382878 reaction equation
Cl[C:2]1[N:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[C:3]=1[C:4]([C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=1)=O.O.[NH2:28][NH2:29]>N1C=CC=CC=1>[C:12]([C:10]1[CH:11]=[C:6]([C:4]2[C:3]3[C:2](=[N:24][C:23]([CH3:25])=[CH:22][C:21]=3[CH3:26])[NH:29][N:28]=2)[CH:7]=[C:8]([C:17]([CH3:19])([CH3:18])[CH3:20])[C:9]=1[OH:16])([CH3:14])([CH3:15])[CH3:13]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14368274HCID 14368274, compound

Product 1

HCID 178423642HCID 178423642, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 18.3 g of 4-(2-chloro-4,6-dimethylnicotinoyl)-2,6-di-tertiary butylphenol, 11 g of hydrazine hydrate and 100 ml of pyridine is reacted and the product is treated in a similar manner as Example 1 to give 15.5 g of 3-(3,5-di-tertiary butyl-4-hydroxyphenyl)-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridine as white crystals, melting at 257°-258° C.

Workup

  1. customis reacted
  2. additionthe product is treated in a similar manner as Example 1

Sources & evidence

ORD record
ord-cefd94c3e86643429fe8d4f436315d6e
Source dataset
uspto-grants-1989_02
Patent number
US04808620

Reaction notes

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