Hydrazine hydrate (1:1) → HCID 178438423, compound

HRID 1382879Notes

Reaction equation

HRID 1382879 reaction equation
Cl[C:2]1[N:24]=[C:23]([CH:25]([CH3:27])[CH3:26])[CH:22]=[CH:21][C:3]=1[C:4]([C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=1)=O.O.[NH2:29][NH2:30]>N1C=CC=CC=1>[C:17]([C:8]1[CH:7]=[C:6]([C:4]2[C:3]3[C:2](=[N:24][C:23]([CH:25]([CH3:26])[CH3:27])=[CH:22][CH:21]=3)[NH:30][N:29]=2)[CH:11]=[C:10]([C:12]([CH3:14])([CH3:13])[CH3:15])[C:9]=1[OH:16])([CH3:18])([CH3:19])[CH3:20]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14368275HCID 14368275, compound

Product 1

HCID 178438423HCID 178438423, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 4-(2-chloro-6-isopropylnicotinoyl)-2,6-di-tertiary butylphenol and hydrazine hydrate in pyridine is refluxed. After the pyridine is distilled off, to the residue is added water. The resulting crystals are recrystallized from ethanol to give 3-(3,5-di-tertiary butyl-4-hydroxyphenyl)-6-isopropyl-1H-pyrazolo[3,4-b]pyridine.

Workup

  1. distillationAfter the pyridine is distilled off, to the residue
  2. additionis added water
  3. customThe resulting crystals are recrystallized from ethanol

Sources & evidence

ORD record
ord-920a20457b1244a3a79183bb7bcc5935
Source dataset
uspto-grants-1989_02
Patent number
US04808620

Reaction notes

Loading…