Phosphorus oxychloride → HCID 88493727, compound

Participants

Reaction Steps

Methanol (100 ml) was ice-cooled and 2.15 g of phosphorus oxychloride was added dropwise under stirring. To this mixture was added 5.49 g (6.91 mmole) of 7-[2-(2-formylamino-1,3-thiazol-4-yl)-2-(3-formylcarbazoyl)carbonylaminoacetamido]-3-[(1,3,4-thiadiazol-2-yl)thiomethyl]-3-cephem-4-carboxylic acid diphenylmethyl ester obtained in Reference example 57, and the mixture was stirred for 3 hours under ice-cooling.

Provenance & Evidence