Phosphorus oxychloride → HCID 88493727, compound

HRID 1383130Notes

Reaction equation

HRID 1383130 reaction equation
P(Cl)(Cl)([Cl:3])=O.[C:6]1([CH:12]([O:19][C:20]([C:22]2[N:27]3[C:28](=[O:51])[CH:29]([NH:30][C:31](=[O:50])[CH:32]([C:42]4[N:43]=[C:44]([NH:47]C=O)[S:45][CH:46]=4)[NH:33][C:34]([C:36](=[O:41])[NH:37][NH:38]C=O)=[O:35])[C@H:26]3[S:25][CH2:24][C:23]=2[CH2:52][S:53][C:54]2[S:55][CH:56]=[N:57][N:58]=2)=[O:21])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CO>[ClH:3].[ClH:3].[C:6]1([CH:12]([O:19][C:20]([C:22]2[N:27]3[C:28](=[O:51])[CH:29]([NH:30][C:31](=[O:50])[CH:32]([C:42]4[N:43]=[C:44]([NH2:47])[S:45][CH:46]=4)[NH:33][C:34]([C:36](=[O:41])[NH:37][NH2:38])=[O:35])[C@H:26]3[S:25][CH2:24][C:23]=2[CH2:52][S:53][C:54]2[S:55][CH:56]=[N:57][N:58]=2)=[O:21])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 88493724HCID 88493724, compound

Product 1

HCID 88493727HCID 88493727, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanol (100 ml) was ice-cooled and 2.15 g of phosphorus oxychloride was added dropwise under stirring. To this mixture was added 5.49 g (6.91 mmole) of 7-[2-(2-formylamino-1,3-thiazol-4-yl)-2-(3-formylcarbazoyl)carbonylaminoacetamido]-3-[(1,3,4-thiadiazol-2-yl)thiomethyl]-3-cephem-4-carboxylic acid diphenylmethyl ester obtained in Reference example 57, and the mixture was stirred for 3 hours under ice-cooling.

Workup

  1. temperaturecooled
  2. customobtained in Reference example 57
  3. stirringthe mixture was stirred for 3 hours under ice-
  4. temperaturecooling

Sources & evidence

ORD record
ord-724b69cca56d447580bd1d29b4869fbe
Source dataset
uspto-grants-1989_02
Patent number
US04808711

Reaction notes

Loading…