反应详情

The product of Example 2 (3 g, 0.0052 mol) was dissolved in ethanol (50 ml). Aqueous lithium hydroxide solution (2M, 9.2 ml) was added and the reaction solution was stirred at room temperature for 3 hrs. Ethanol was removed using the rotary evaporator and the aqueous residue was acidified to pH2 using aqueous 0.5N sodium bisulfate solution. The oil which separated was extracted with ethyl acetate and the organic layer dried over anhydrous magnesium sulfate. The drying agent was filtered and the filtrate concentrated on the rotary evaporator to give 2.53 g of a colorless oil which was dried at 70° (0.1 mm Hg) for 5 hrs to give the title compound.

1. customEthanol was removed
2. customthe rotary evaporator
3. customThe oil which separated
4. extractionwas extracted with ethyl acetate
5. dry with materialthe organic layer dried over anhydrous magnesium sulfate
6. filtrationThe drying agent was filtered
7. concentrationthe filtrate concentrated on the rotary evaporator