2-Amino-2-methyl-1,3-propanediol → 1,3-Propanediol, 2-((7-fluoranthenylmethyl)amino)-2-methyl-, hydrochloride

HRID 1383172Notes

Reaction equation

[ClH:1].C1C2=C3C(C4C2=CC=CC=4)=CC=CC3=C(CNC(C)(CO)CO)C=1.[CH:26]1[C:40]2=[C:41]3[C:33]([C:34]4[C:35]([CH:42]=O)=[CH:36][CH:37]=[CH:38][C:39]=42)=[CH:32][CH:31]=[CH:30][C:29]3=[CH:28][CH:27]=1.[NH2:44][C:45]([CH3:50])([CH2:48][OH:49])[CH2:46][OH:47]>>[ClH:1].[CH:26]1[C:40]2=[C:41]3[C:33]([C:34]4[C:39]2=[CH:38][CH:37]=[CH:36][C:35]=4[CH2:42][NH:44][C:45]([CH3:50])([CH2:48][OH:49])[CH2:46][OH:47])=[CH:32][CH:31]=[CH:30][C:29]3=[CH:28][CH:27]=1

Participants

Reactant 3

HCID 15312-Amino-2-methyl-1,3-propanediol

HCID 3024572773U82 Hydrochloride

HCID 133754137-Fluoranthenecarbaldehyde

Product 1

HCID 30365791,3-Propanediol, 2-((7-fluoranthenylmethyl)amino)-2-methyl-, hydrochloride

Procedure

Using the reductive amination procedure outlined in 1D, 7-fluoranthenecarbaldehyde (1B) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave 2-((7-fluoranthenylmethyl)amino)-2-methyl-1,3-propanediol hydrochloride mp 204°-206° (dec), (CH3OH/Et2O), (C,H,Cl,N).

Sources & evidence

ORD record: ord-8735d3bff652454fbf5dd226e33a9b0c
Source dataset: uspto-grants-1989_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04808632

Reaction notes

Loading…