2,2,2-Trifluoroethanol → HCID 13372616, compound

HRID 1383211Notes

Reaction equation

HRID 1383211 reaction equation
[CH3:1][C:2]1([CH3:30])[C@@H:4](/[CH:5]=[C:6](/[F:10])\[C:7](=[O:9])[OH:8])[C@H:3]1[C:11]([O:13][C@H:14]([C:28]#[N:29])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:16]=1)=[O:12].[F:31][C:32]([F:36])([F:35])[CH2:33]O>C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:30])[C@@H:4](/[CH:5]=[C:6](/[F:10])\[C:7](=[O:8])[O:9][CH2:33][C:32]([F:36])([F:35])[F:31])[C@H:3]1[C:11]([O:13][C@H:14]([C:28]#[N:29])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:16]=1)=[O:12]

Participants

4

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 15589467HCID 15589467, compound

Product 1

HCID 13372616HCID 13372616, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

(S)α-cyano-3-phenoxy-benzyl (1R,cis,E) 2,2-dimethyl-3-(2-fluoro-3-oxo-3-hydroxy-1-propenyl)-cyclopropane carboxylate and 2,2,2-trifluoro-ethanol were reacted to obtain (S)α-cyano-3-phenoxy-benzyl (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-(2,2,2-trifluoroethoxy)-1-propenyl]-cyclopropanecarboxylate with a specific rotation of [α]D20 =+36.5°±2° (c=0.5% in chloroform).

Sources & evidence

ORD record
ord-6c5c768aa93241ce84cf4a74577998e9
Source dataset
uspto-grants-1989_02
Patent number
US04808749

Reaction notes

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