反应详情

95 g (0.2 mol) of (6-carboxyhexyl)triphenylphosphonium bromide in 600 ml of tetrahydrofuran were added to 48 g (0.42 mol) of potassium t-butylate in 200 ml of tetrahydrofuran. Thereafter, 29 g (0.18 mol) of 8-hydroxy-6-methyl-2-octanone were added. After work up and chromatography 26 g (48%) of 14-hydroxy-8,12-dimethyltetradec-7-enoic acid were obtained having the following characteristics: Z/E=58/42;