Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
8-Hydroxy-6-methyl-2-octanone → 14-Hydroxy-8,12-dimethyltetradec-7-enoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 8-Hydroxy-6-methyl-2-octanone | HCID 9815269 | — |
| 반응물 | (6-Carboxyhexyl)triphenylphosphonium bromide | HCID 11027094 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 14-Hydroxy-8,12-dimethyltetradec-7-enoic acid | HCID 73753004 | 53.4% |
반응 단계
95 g (0.2 mol) of (6-carboxyhexyl)triphenylphosphonium bromide in 600 ml of tetrahydrofuran were added to 48 g (0.42 mol) of potassium t-butylate in 200 ml of tetrahydrofuran. Thereafter, 29 g (0.18 mol) of 8-hydroxy-6-methyl-2-octanone were added. After work up and chromatography 26 g (48%) of 14-hydroxy-8,12-dimethyltetradec-7-enoic acid were obtained having the following characteristics: Z/E=58/42;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06255276B1 |
| 출처 데이터셋 | uspto-grants-2001_07 |
| ORD ID | ord-d809ceb78d584b6f8f6d8126318032d7 |
| 출처 메모 | uspto-grants-2001_07 |