Potassium Carbonate → Isoambrettolide, (Z)-

Participants

Reaction Steps

40 g (0.29 mol) of potassium carbonate were suspended in finely pulverized form in 600 mg of N-methylpyrrolidone. 49 g (0.147 mol) of Z-16-bromohexadec-9-enoic acid in 300 ml of N-methylpyrrolidone were added dropwise within 6 hours. A standard work up was effected; bulb-tube distillation and recrystallization gave 19 g (51%) of 10Z-oxacydoheptadec-10-en-2-one were obtained having the following characteristics: Z/E=98/2;

Provenance & Evidence