Acetic Anhydride → HCID 18180200, compound

HRID 1383311Notes

Reaction equation

HRID 1383311 reaction equation
[NH2:1][C:2]1[C:7]([Br:8])=[N:6][CH:5]=[C:4]([NH2:9])[N:3]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>COC(OC)C>[NH2:1][C:2]1[C:7]([Br:8])=[N:6][CH:5]=[C:4]([NH:9][C:10](=[O:12])[CH3:11])[N:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18180211HCID 18180211, compound

Product 1

HCID 18180200HCID 18180200, compound

Reagents, catalysts & solvents 1

HCID 107951,1-DimethoxyethaneSolvent

Procedure

A mixture of 2,6-diamino-3-bromopyrazine (10.50 g, 0.056 mole) in dry 1,1-dimethoxyethane (168 ml) and acetic anhydride (7.91 ml, 8.56 g, 0.084 mole) was refluxed under nitrogen for 2.50 hrs. The cooled mixture was evaporated in vacuo. The residue was triturated with ether, filtered and dried in vacuo. Yield 10.31 g (80%), M.p. 218-221° C.

Workup

  1. temperaturewas refluxed under nitrogen for 2.50 hrs
  2. customThe cooled mixture was evaporated in vacuo
  3. customThe residue was triturated with ether
  4. filtrationfiltered
  5. customdried in vacuo

Sources & evidence

ORD record
ord-9baf6d417fd94505879aef8f014d0fa1
Source dataset
uspto-grants-2001_07
Patent number
US06255307B1

Reaction notes

Loading…