Acetic Anhydride → HCID 18180200, compound

Participants

Reaction Steps

A mixture of 2,6-diamino-3-bromopyrazine (10.50 g, 0.056 mole) in dry 1,1-dimethoxyethane (168 ml) and acetic anhydride (7.91 ml, 8.56 g, 0.084 mole) was refluxed under nitrogen for 2.50 hrs. The cooled mixture was evaporated in vacuo. The residue was triturated with ether, filtered and dried in vacuo. Yield 10.31 g (80%), M.p. 218-221° C.

Provenance & Evidence