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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1383340Generated: October 31, 2026

Acetic Acid → HCID 21699317, compound

https://huagongshe.com/reaction/1383340

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantPyrrolidineHCID 31268—
Reactant6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedioneHCID 73273—
SolventWaterHCID 962—
ProductHCID 21699317HCID 2169931729%

Reaction Steps

To a solution of 1.78 g of pyrrolidine in water (20 ml), 1.33 g of 6-chloromethyluracil were added. The resulting mixture was stirred at room temperature for 24 hours and neutralized with acetic acid. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was washed with methanol and then filtered, whereby 466 mg of the title compound were obtained (yield: 29%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06255314B1
Source datasetuspto-grants-2001_07
ORD IDord-d9ce1c81e4cf4e2fb1c4d122472208dc
Source noteuspto-grants-2001_07