Acetic Acid → HCID 21699317, compound

HRID 1383340Notes

Reaction equation

HRID 1383340 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:7][C:8]1[NH:13][C:12](=[O:14])[NH:11][C:10](=[O:15])[CH:9]=1.C(O)(=O)C>O>[N:1]1([CH2:7][C:8]2[NH:13][C:12](=[O:14])[NH:11][C:10](=[O:15])[CH:9]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 31268PyrrolidineHCID 732736-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 21699317HCID 21699317, compoundYield 29%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 1.78 g of pyrrolidine in water (20 ml), 1.33 g of 6-chloromethyluracil were added. The resulting mixture was stirred at room temperature for 24 hours and neutralized with acetic acid. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was washed with methanol and then filtered, whereby 466 mg of the title compound were obtained (yield: 29%).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customThe residue so obtained
  3. washwas washed with methanol
  4. filtrationfiltered

Sources & evidence

ORD record
ord-d9ce1c81e4cf4e2fb1c4d122472208dc
Source dataset
uspto-grants-2001_07
Patent number
US06255314B1

Reaction notes

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