反应详情

A solution of 3,5-dimethoxyphenylacetic acid (2.0 g; 10 mmol) and H2SO4 (conc.; 0.2 mL) in EtOH (50 mL) was refluxed overnight. The solution was concentrated, and the resultant material was dissolved in aqueous NaOH (1M). After extraction with ether (2×75 mL), washing of the combined organic phase with brine, drying (Na2SO4) and evaporating, 2.0 g (88%) of the sub-title compound was obtained.

1. concentrationThe solution was concentrated
2. dissolutionthe resultant material was dissolved in aqueous NaOH (1M)
3. extractionAfter extraction with ether (2×75 mL)
4. washwashing of the combined organic phase with brine
5. dry with materialdrying (Na2SO4)
6. customevaporating