反应详情

To a solution of 2-bromo-5-methoxybenzaldehyde (5.0 g, 23.2 mmol) in toluene (300 mL) was added ethanediol (2.16 g, 34.2 mmol) and p-TsOH (20 mg), whereafter the mixture was refluxed for 12 hours. The resulting mixture was cooled to room temperature, washed with NaHCO3/aq, dried (Na2SO4), and concentrated to yield 5.918 g (98%) of the sub-title compound.

1. temperaturewhereafter the mixture was refluxed for 12 hours
2. washwashed with NaHCO3/aq
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated