Boron tribromide → HCID 21188003, compound

HRID 1383429Notes

Reaction equation

HRID 1383429 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:19]([CH3:20])=[N:18][C:17]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[N:16]1)C1C=CC=CC=1.B(Br)(Br)Br>ClCCl>[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:19]([CH3:20])=[N:18][C:17]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[N:16]1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 21188008HCID 21188008, compound

Product 1

HCID 21188003HCID 21188003, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent3×

Procedure

1 g of 1-(2-benzyloxyphenyl)-5-methyl-3-phenyl-1,2,4-triazole are dissolved in 20 ml of anhydrous dichloromethane and a solution of 0,5 ml of BBr3 in 10 ml of dichloromethane is added dropwise. After 3 hours stirring at ambient temperature the mixture is diluted with a further 100 ml of dichloromethane and washed twice with water. After the organic phase has been dried over Na2SO4 the solvent is distilled off. The crude product remaining is purified by chromatography on silica gel (toluene:ethyl acetate 80:20).

Workup

  1. washwashed twice with water
  2. dry with materialAfter the organic phase has been dried over Na2SO4 the solvent
  3. distillationis distilled off
  4. customThe crude product remaining is purified by chromatography on silica gel (toluene:ethyl acetate 80:20)

Sources & evidence

ORD record
ord-cd51d1df99594314a4d46e0c6fec4f05
Source dataset
uspto-grants-2001_07
Patent number
US06255327B1

Reaction notes

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