Boron tribromide → HCID 21188003, compound

Participants

Reaction Steps

1 g of 1-(2-benzyloxyphenyl)-5-methyl-3-phenyl-1,2,4-triazole are dissolved in 20 ml of anhydrous dichloromethane and a solution of 0,5 ml of BBr3 in 10 ml of dichloromethane is added dropwise. After 3 hours stirring at ambient temperature the mixture is diluted with a further 100 ml of dichloromethane and washed twice with water. After the organic phase has been dried over Na2SO4 the solvent is distilled off. The crude product remaining is purified by chromatography on silica gel (toluene:ethyl acetate 80:20).

Provenance & Evidence