Water → HCID 21188056, compound

HRID 1383579Notes

Reaction equation

HRID 1383579 reaction equation
[Br:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#N)[C:3]=1[C:21]#[C:22][Si](C)(C)C.[C:27](=O)([O-])[O-:28].[K+].[K+].CC[O:35]CC.O>CO>[Br:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]([O:28][CH3:27])=[O:35])[C:3]=1[CH2:21][CH3:22]

Participants

6

Reactant 4

HCID 962WaterHCID 3283Diethyl EtherHCID 11430Potassium Carbonate2×HCID 21188048HCID 21188048, compound

Product 1

HCID 21188056HCID 21188056, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 5-bromo-3-cyano-1-(2,6-dichloro-4-trifiluoromethylphenyl)-4-trimethylsilylethynylpyrazole (100 mg, the compound of Example C1) in methanol (1 ml) was added potassium carbonate (2.9 mg). Stirring was continued at room temperature for 2 hours and then potassium carbonate (3.0 mg) was added. Stirring was continued for a further 4 hours. The reaction mixture was then poured into ether (10 ml) and water (10 ml). The organic layer was separated, dried (MgSO4) and evaporated to provide the title compound as a white solid m.p. 198° C. (decomp.).

Workup

  1. stirringStirring
  2. waitwas continued for a further 4 hours
  3. customThe organic layer was separated
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-00dd1ba99be2453dabea96d5f9a923aa
Source dataset
uspto-grants-2001_07
Patent number
US06255333B1

Reaction notes

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