Hydrochloric Acid → 2-(4-Benzyl-1-piperazinyl)ethoxyacetic acid dihydrochloride

HRID 1383758Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][CH2:17][C:18](N)=[O:19])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:21].[OH2:22]>CC(C)=O>[ClH:21].[ClH:21].[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][CH2:17][C:18]([OH:19])=[O:22])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 60 °C

Procedure

III.1A. 13.9 g (0.05 mol) of 2-(4-benzyl-1-piperazinyl)ethoxyacetamide are dissolved in 15 ml of water in a 100 ml three-necked round-bottomed flask fitted with a water-cooled condenser and a mechanical stirrer. 31 ml (0.375 mol) of aqueous 37% hydrochloric acid solution are added. The mixture is heated at 60° C. for 1 hour. The water is removed on a rotary evaporator under reduced pressure at 60° C. The white solid obtained is taken up in 75 ml of acetone and is stirred for 1 hour at room temperature. The mixture is filtered and 19.7 g of 2-(4-benzyl-1-piperazinyl)ethoxyacetic acid dihydrochloride are obtained in the form of white crystals.

Workup

temperaturecooled condenser and a mechanical stirrer
customThe water is removed on a rotary evaporator under reduced pressure at 60° C
customThe white solid obtained
filtrationThe mixture is filtered

Sources & evidence

ORD record: ord-ee88a182926d4dd9acc9d3d441e44cdf
Source dataset: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06255487B1

Reaction notes

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