HCID 21187675, compound → 4-(2-Methoxyphenyl)cyclohexan-1-one

HRID 1383765Notes

Reaction equation

HRID 1383765 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH:11]=[CH:10]1>[Pd].C(OC(=O)C)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 21187675HCID 21187675, compound

Product 1

HCID 211876704-(2-Methoxyphenyl)cyclohexan-1-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of palladium on carbon (3.75 g, 25% wt) in 200 mL ethylacetate was added a 1:2 mixture of 4-(2-Melhoxy-phenyl)-cyclohex-3-enone and 4-(2-Methoxy-phenyl)-cyclohex-2-enone (15 g, 75.0 mmol) under argon. The suspension was stirred under a hydrogen at 1 atm. for 6.5 h, filtered through celite,concentrated in vacuo, and crystallized from ethylacetate to give 4-(2-Methoxy-phenyl)-cyclohexanone.

Workup

  1. additionwas added
  2. filtrationfiltered
  3. customcrystallized from ethylacetate

Sources & evidence

ORD record
ord-0627e9de1e804098b1c2c5573ba255e5
Source dataset
uspto-grants-2001_07
Patent number
US06255315B1

Reaction notes

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