反应详情

To a solution of 8-(2-fluorophenyl)-1,4-dioxa-spiro[4.5]decan-8-ol (5.8 g, 23 mmol) in dioxane (100 mL), cooled to 0° C. was added hydrogen chloride (1M in water, 75 ml, 75 mmol). The reaction mixture was stirred for 2 hour at room temperature, extracted with ethyl ether (2×200 mL) and washed with saturated bicarbonate solution, water and brine. Drying and solvent evaporation gave 4-(2-Fluorophenyl)-4-hydroxy-cyclohexanone in quantitative yield.

1. extractionextracted with ethyl ether (2×200 mL)
2. washwashed with saturated bicarbonate solution, water and brine
3. customDrying
4. customsolvent evaporation