反应详情

To a solution of 14.6 g (67.19 mmol) of 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)pyridine in ethyl acetate (400 mL) was added 4.6 g of 10% palladium on carbon catalyst. The resulting suspension was then hydrogenated at ambient temperature and atmospheric pressure until all the starting material was consumed (10.5 hr). The reaction mixture was filtered through celite and the filtrate was concentrated to give the product as an oily solid.

1. customwas then hydrogenated at ambient temperature
2. customatmospheric pressure until all the starting material was consumed (10.5 hr)
3. filtrationThe reaction mixture was filtered through celite
4. concentrationthe filtrate was concentrated