反应详情

温度

60 °C

Codeine base (4.0002 g; 12.60 mmol) was dissolved in ethanol (100 mL; 99.7-100%) with stirring. Lauric acid (2.7822 g; 13.86 mmol; 10% excess relative to codeine base) was dissolved in the ethanol/codeine solution. The resulting solution was stirred for 5 minutes. The ethanol was removed by rotary-evaporation to give a pale yellow residue. The residue was redispersed in ethyl acetate (10 mL) by heating on a water bath (60° C.). Once all the material had redissolved the solution was placed at 4° C. for 16 hours. A white precipitate formed which was isolated by vacuum filtration. The precipitate was dried further in a vacuum oven for 16 hours at 40° C. to give codeine laurate (2.4757 g; 36.50%). The material was analysed by Differential Scanning Calorimetry in order to determine the melting point. However, thermal analysis from 50 to 200° C. showed no thermal event.

1. stirringThe resulting solution was stirred for 5 minutes
2. customThe ethanol was removed by rotary-evaporation
3. customto give a pale yellow residue
4. dissolutionOnce all the material had redissolved the solution
5. customA white precipitate formed which
6. customwas isolated by vacuum filtration
7. customThe precipitate was dried further in a vacuum oven for 16 hours at 40° C.