Hydrazine hydrate (1:1) → HCID 22288370, compound

HRID 1383827Notes

Reaction equation

HRID 1383827 reaction equation
O.[NH2:2][NH2:3].[Cl:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](Cl)=[N:7][N:6]=1>C(O)C>[ClH:4].[Cl:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([NH:2][NH2:3])=[N:7][N:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 784901,4-Dichlorophthalazine

Product 1

HCID 22288370HCID 22288370, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a stirred solution of hydrazine hydrate (40 ml) in ethanol (120 ml) at 80° C. was added 1,4-dichlorophthalazine (20 g). This reaction mixture was stirred at 80° C. for 0.5 hours, then left to cool and the product was collected by filtration and dried under vacuum to give 1-chloro-4-hydrazinophthalazine hydrochloride (14.6 g). 1H NMR (250 MHz, DMSO) δ 4.64 (2H, vbs), 7.2 (1H, vbs), 7.92 (4H, bm).

Workup

  1. waitleft
  2. temperatureto cool
  3. filtrationthe product was collected by filtration
  4. customdried under vacuum

Sources & evidence

ORD record
ord-101455e0d1bc425a815ec9469ddc589f
Source dataset
uspto-grants-2001_07
Patent number
US06255305B1

Reaction notes

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