HRID1383871

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)CCl

HCID9926241

tert-Butyl [(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate

C15H20ClNO3

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CCl

HCID7146645

tert-Butyl [(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate

C15H22ClNO3

CONDITIONS

反应条件

温度: 25 °C

PROCEDURE

实验过程

To the thus-prepared reducing agent was added 298 mg (1.0 mmol) of [1(S)-benzyl-2-oxo-3-chloropropyl]carbamic acid t-butyl ester, and the mixture was stirred at 25° C. for 16 hours. After hydrolysis with 1 N hydrochloric acid, the reaction mixture was extracted with ethyl acetate.

WORKUP

后处理

extractionthe reaction mixture was extracted with ethyl acetate