2-(Methylamino)ethanol → Dodecyl(2-hydroxyethyl)methylamine

HRID 1383893노트

반응식

HRID 1383893 반응식
I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[CH3:14][NH:15][CH2:16][CH2:17][OH:18]>C(O)(C)C.CCOCC>[CH3:14][N:15]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH2:16][CH2:17][OH:18]

참가 물질

5

반응물 2

HCID 80162-(Methylamino)ethanolHCID 202821-Iodododecane

생성물 1

HCID 10657884Dodecyl(2-hydroxyethyl)methylamine수율 97.5%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 3776Isopropanol용매

실험 절차

A solution of iodododecane (18.1 g, 61.09 mmol) and 2-(methylamino)ethanol (23.0 g, 0.3 mol) in isopropanol (75 ml) was heated under reflux for 3 h. The cooled mixture was diluted with ether (500 ml), washed with water, brine and dried (magnesium sulfate). Evaporation of the solvent under reduced pressure and distillation of the residue under vacuum gave 14.5 g (97%) of N-methyl-N-dodecylethanolamine as a clear oil: b.p. 100-111° C./0.3 torr (bulb to bulb distillation, air bath temperature).

후처리

  1. temperatureunder reflux for 3 h
  2. washwashed with water, brine
  3. dry with materialdried (magnesium sulfate)
  4. customEvaporation of the solvent
  5. distillationunder reduced pressure and distillation of the residue under vacuum

출처 및 근거

ORD 기록
ord-d11c8ac4737f468198028b56334fd7aa
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06255496B1

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