4-[4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]1,1,1-trifluoro-2-butanone → 4-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-methoxyphenyl]-1,1,1-trifluoro-2-butanone

HRID 1383902Notes

Reaction equation

HRID 1383902 reaction equation
Cl.[CH2:2]([N:14]([CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([OH:29])=O)=[C:21]([O:30][CH3:31])[CH:20]=1)[CH3:15])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].C(N(CCOC1C=CC(CCC(=O)[C:58]([F:61])([F:60])[F:59])=CC=1)C)CCCCCCCCCCC>>[CH2:2]([N:14]([CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27](=[O:29])[C:58]([F:61])([F:60])[F:59])=[C:21]([O:30][CH3:31])[CH:20]=1)[CH3:15])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 99550834-[4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]1,1,1-trifluoro-2-butanoneHCID 1317227593-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-methoxyphenyl]propanoic acid, hydrochloride

Product 1

HCID 183190324-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-methoxyphenyl]-1,1,1-trifluoro-2-butanoneYield 58%

Procedure

3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-methoxyphenyl]propanoic acid, hydrochloride (274 mg, 0.598 mmol) was reacted by the general procedure as described in the preparation of 4-[4-[2-(N-dodecyl-N-methylamino)- ethoxy]phenyl]-1,1,1-trifluoro-2-butanone and afforded the title compound (165 mg, 58%) as a pale yellow oil (b.p. 138-140° C./0.015 mmHg).

Sources & evidence

ORD record
ord-a280238daedc4605a671dd4ccdd8e411
Source dataset
uspto-grants-2001_07
Patent number
US06255496B1

Reaction notes

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